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Educate patients that: Gastrointestinal side effects are common early on Symptoms are typically temporary and improve over time Side effects are often more noticeable during dose escalation Providers can adjust dosing if symptoms become difficult to manage 2

These combined effects result in improved glycaemic control, weight reduction, and potential cardiovascular benefits for specific agents

Instead, they should explore low-cost FDA-approved options and consult with a clinician about switching

Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells

It is thought to do this by stimulating human growth receptors in injured tissue